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Presentations
BUCCOLAM® is available in four unit-dose, age-specific, colour-coded, pre-filled oral syringes.4
BUCCOLAM® potentially provides an ~50% cost saving per dose compared to Epistatus®5.
Prescribe by brand to ensure your patients receive BUCCOLAM®.
| Dosage | Cost per dose/syringe5 | List price5 | Shelf-life (months)1,7 |
|---|---|---|---|
|
BUCCOLAM®
Epistatus®
|
BUCCOLAM® (4 syringes pack)
Epistatus® (1 syringe pack)
|
BUCCOLAM®
Epistatus®
|
|
| 2.5 mg |
£20.50
£43.75
|
£82.00
£43.75
|
18
18
|
| 5 mg |
£21.38
£43.75
|
£85.50
£43.75
|
24
18
|
| 7.5 mg |
£22.25
£43.75
|
£89.00
£43.75
|
24
18
|
| 10 mg |
£22.88
£45.76
|
£91.50
£45.76
|
24
18
|
References
1. Buccolam 2.5 mg , 5 mg, 7.5 mg and 10 mg Summaries of Product Characteristics
2. Wang J, Sun P, Liang P. Neuropsychopharmacological effects of midazolam on the human brain. Brain Inform. 2020 Nov 10;7(1):15.
3. Gidal B, Detyniecki K. Rescue therapies for seizure clusters: Pharmacology and target of treatments. Epilepsia. 2022 Sep;63 Suppl 1(Suppl 1):S34-S44.
4. Lingamchetty TN, Hosseini SA, Saadabadi A. Midazolam. [Updated 2023 Jun 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537321/ [Accessed December 2025]
5. BNF. Midazolam medicinal forms. Available at: https://bnf.nice.org.uk/drugs/midazolam/medicinal-forms/#oromucosalsolution (accessed: December 2025).
6. Epistatus® 2.5mg, 5 mg, 7.5 mg, 10 mg oromucosal solution Summary of Product
Characteristics.
7. Community Pharmacy England. Search results for Medicine Supply Notification: Midazolam. Available at: https://cpe.org.uk/?s=Medicine+Supply+Notification%3A+Midazolam&post_type=all (accessed: December 2025).
This information is intended for use by healthcare professionals.
NXUK/E/1125/01 December 2025
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